Definition:
PDE-4 inhibition refers to the blocking of the enzyme phosphodiesterase-4 (PDE-4), which is responsible for breaking down cAMP (cyclic adenosine monophosphate) in the brain. By inhibiting this enzyme, compounds like mesembrine found in kanna increase cAMP levels—boosting signaling involved in mood regulation, cognition, and inflammation control.
Why It Matters:
PDE-4 inhibition is a major mechanism behind kanna’s calming and antidepressant-like effects. It also explains why kanna may improve focus and emotional resilience without overstimulation.
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Further Reading:
See the full breakdown on the What is Kanna page.
Related Terms:
