Definition:
Mesembrine is the primary active alkaloid found in the kanna plant (Sceletium tortuosum). It is largely responsible for the mood-enhancing and anxiolytic effects users report
Further reading – What is kanna?
What it does:
Mesembrine is known to affect the brain through multiple pathways:
- Serotonin Reuptake Inhibition (SRI): Increases the amount of serotonin in the brain by preventing its reabsorption.
- PDE-4 Inhibition: Can reduce inflammation and enhance mood/cognition by modulating intracellular signaling.
- VMAT-2 Upregulation: Supports the packaging and release of neurotransmitters like dopamine, serotonin, and norepinephrine.
This combination makes mesembrine one of the most pharmacologically interesting natural compounds for emotional regulation and nervous system support.
Why it matters:
The mesembrine content in a kanna product can influence how stimulating or calming it feels. Products higher in mesembrine tend to be more uplifting and energizing.
Check out – Where to buy kanna near me – for help choosing the right product.
Related Terms:
